PROBIOTICS – live microbes, components of the normal microflora, which fall into their composition. At the same time, they suppress pathogenic strains and strengthen the barrier function of the intestinal tract, as well as participate in the synthesis and assimilation of substances that are needed by the body, incl. amino acids, fatty acids, various coenzymes and vitamins.
 PREBIOTICS– substances that in unchanged form reach the various parts of the intestinal tract, where they stimulate the development and activity of certain groups of probiotic microorganisms, increase the functional status of the immune system.
 SYNBIOTICS – complex preparations of the latest generation, which include probiotics and prebiotics. Synbiotics combine all the healing properties of probiotics and prebiotics.

ENTEROFLORID is a complex, four- component SYNBIOTIC with a proven high effect in the prevention and treatment of dysbiosis (dysbacteriosis) of various etiologies, as well as in other dysfunctions of the gastrointestinal tract.
The intestinal microbiocenosis is an open ecological system of various microorganisms inhabiting the gastrointestinal tract of a healthy person. Disruption of the microbiocenosis, etc. Dysbiosis (dysbacteriosis) is a complex syndrome that manifests itself in a violation of the normal qualitative and quantitative balance of the microbial population in the gastrointestinal tract.

Dysbiosis (dysbacteriosis) causes a number of pathological conditions in the human body.

Main causes of DYSBIOSIS (DYSBACTERIOSIS): 

 Various disorders of the gastrointestinal tract
 Weakening of the immune system
 Various infectious diseases
 Environmental pollution
 Stressful conditions
 Incomplete, incl. malnutrition
 Intake of antibiotics

The main method of treatment of dysbiosis (dysbacteriosis) is by external replenishment of the intestinal microflora with deficient components of the normal microflora, and also creating conditions in the intestinal tract for their selective reproduction and suppression of pathogenic flora.

A study of a large number of patients (more than 1,200 people) for the period September-December 2008, who turned to the diagnostic laboratory at the Institute of Bacteriophagy, Microbiology and Virology at the Academy of Sciences of Georgia with complaints related to the gastrointestinal tract, allows to 1040 different forms of dysbiosis (dysbacteriosis) are diagnosed, including against the background of the presence of pathogenic microflora (Table 1)

Number of patients (% of total diagnosed)
Period Dysbiosis(dysbacteriosis) dysbiosis (dysbacteriosis) in the background on pathogenic and conditionally pathogenic microflora Total
September 205
(74,5%)		 70
(25,5%)		 275
(100%)
October 223
(74%)		 78
(26%)		 301
(100%)
November 192
(80%)		 47
(20%)		 239
(100%)
December 194
(86%)		 31
(14%)		 225
(100%)
Total 814
(78%)		 226
(22%)		 1040
(100%)

The analysis of the results of the research of the patients in whom different forms of dysbiosis (dysbacteriosis) were diagnosed allows to determine four conditional groups of dysbiosis (dysbacteriosis) depending on the deficient microflora (Table 2).

Relative frequency of the forms of dysbiosis (dysbacteriosis), with microflora of different deficiency

№ group Deficiency by species of normal microflora % of total patients (1040) diagnosed with dysbiosis (dysbacteriosis)
Group I
(one-component deficit)		 bifidobacterium
lactobacterium
E. Coli
Enterococsus		 7%
(73 people)
Group II
(two-component deficit)		 bifido + lacto
bifido + E.Coli
bifido + entero
lacto + E.Coli
lacto + entero
E.Coli + entero		 28%
(291 people)
Group III
(three-component deficit)		 bifido + lacto + E.Coli
bifido + lacto + entero
bifido + E.Coli + entero
lacto + E.Coli + entero		 43%
(447 people)
Group IV
(four-component deficit)		 Lacto + Bifidus + E. coli + entero 22%
(229 people)

These data show a high percentage of forms of dysbiosis (dysbacteriosis) associated with simultaneous deficiency of three and four main components of the normal intestinal microflora – 65%, ie. two thirds of all diagnosed cases of dysbiosis (dysbacteriosis).
 Obviously, only a complex synbiotic preparation, which contains all four strains of these probiotic microorganisms and the environment for their development (prebiotic), will be able to simultaneously fill the deficit in the normal intestinal microflora of its main components: Bifidobacteria, Lactobacilli, Escherichia coli and Enterococci.

In Table 3 is shown a set of strains of the aforementioned probiotic microorganisms are most frequently used for the treatment of dysbiosis (dysbiosis)

Families and strains of probiotic microorganisms most commonly used in preparations against dysbiosis (dysbacteriosis), and their function in the intestinal microbiocenosis

The Strain family Function in the intestinal microbiocenosis
Bifidobacteria
(Bifidobacteria)
Bifidobacterium bifidum I
Bifidobacterium bifidum longum
Bifidobacterium breve
Bifidobacterium infantis
  • Building a barrier on the intestinal wall against toxins and pathogenic microbes;
  • Participation in the synthesis of amino acids, proteins, pantothenic acid and vitamins B1, B2, B3, B6, B9, K;
  • Absorption of calcium, iron and Vitamin D from the intestinal lumen
Lactobacillus
(Lactobacillus)
Lactobacillus acidofillus
Lactobacillus casei
Lactobacillus fermenti
Lactobacillus lactis
Lactobacillus plantarum
  • Building a barrier on the intestinal wall against toxins and pathogenic microbes;
  • Synthesis of lactic acid, lysocin, lactolin, lactocidin and hydrogen peroxide;
  • Suppression of the reproduction of purulent and opportunistic bacteria through the products of their metabolism
Enterobacteriaceae
with complete fermentation
(Escherichia)
E.Coli M17
  • Providing lactose hydrolysis;
  • Participation in the synthesis of B and K vitamins;
  • Production of colicin, which inhibits the growth of pathogenic intestinal colibacteria;
  • Stimulating the production of antibodies;
  • Increasing the body’s immunity.
Enterococcae
(Enterococcae)
Streptococcus faesium
Streptococcus thermophilus
  • Suppression of the development of a large group of pathogenic and opportunistic bacteria;
  • Restoration of the normal intestinal microbiocenosis

In Table 4 are listed the most commonly used prebiotic components in the composition of the synbiotic preparations

Prebiotic components most commonly used in synbiotic preparations

Prebiotic components Mechanism of action
Oligosaccharides
with degree of polymerization 2-10

  • Fructooligosaccharide (FOS)
  • Lactulose
  • Galactooligosaccharide (GOS)

Polysaccharides
with a degree of polymerization above 80

  • Inulin
  • They pass through the upper part of the gastrointestinal tract and in unchanged form are concentrated in the lower part of the intestine (large intestine), where substrates for the normal intestinal microflora appear.
  • Excipients that enhance the action of probiotic components

ENTEROFLORID – MECHANISM OF ACTION:
stimulates the settlement and development in the intestine of these agents on normal (useful) microflora, whose deficiency is diagnosed
simultaneously effective in all forms of dysbiosis (dysbacteriosis) – group I, group II, group III, and group IV
 resistant to sulfanilamide preparations and antibiotics from the group: penicillin, lincomycin, aminoglycosides and tetracycline
 normalizes and maintains microbiocenoses gastrointestinal tract
 removes as symptoms of dysfunction of the gastrointestinal tract, and the causes of their occurrence – dysbiosis (dysbacteriosis)
improves metabolic processes, prevents the formation of long forms of intestinal diseases, increases the nonspecific resistance of the organism
 suppresses the development of pathogenic (unfavorable) microorganisms in the gut
 are no contraindications and side effects

ENTEROFLORID – Composition:
Each capsule of 300 mg contains:
Probiotic component: live lyophilic dried cells, components of the normal intestinal microflora, a total of not less than 10 8 (one hundred million) including the content of the individual components:

  • Bifidobacteria

(Bifidobacterium bifidum I, Bifidobacterium longum)

 not less than 10 6
  • Lactobacilli

(Lactobacillus fermentum, Lactobacillus plantarum, Lactobacillus acidofillum)

 not less than 10 6
  • E. coli

(E.Coli M-17)

 not less than 10 6
  • Enterococci

(Enterococcus faecium)

 not less than 10 6

Prebiotic component: inulin – 25 mg, fructooligosaccharide (FOS) – 25 mg
Other ingredients: lactose – 50 mg, potato starch to form a capsule of 300 mg

ENTEROFLORID is intended for adults and children over 1 year suffering from the following diseases of the gastrointestinal tract. tract:
dysbiosis (dysbacteriosis) of different etiology, including arising from the adoption of:
– antibiotics
– sulfanilamide preparations
 acute and chronic gastroenterokolit
dysfunction of the gut or excretion of pathogenic and uslovnopatogenni microorganisms
 in postklinichniya period after suffering acute intestinal diseases

ENTEROFLORID – DOSAGE AND METHOD OF ADMINISTRATION:
Adults: 1 capsule 3 times a day, or 1 capsule 2 times a day (morning and evening), 20-30 minutes before meals.
Children: from 1 to 2 years – 2 capsules 2 times a day; from 2 to 12 years – 1 capsule 2 times a day, 20-30 minutes before meals.
In young children, it is recommended that the contents of the capsule be dissolved in a small amount of boiled water at room temperature and drunk as a suspension.
Duration of use: The duration of one course is 1-2 weeks, and depending on the condition can last up to 1 month.

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